Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 11/20 | 0.38 |
| ▸ | HTR1B | P28222 | 11/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 4/20 | 0.33 |
| ▸ | ACHE | P22303 | 4/20 | 0.33 |
| ▸ | TACR2 | P21452 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3427309 | 0.83 | OPRM1 (0.42) | HTR1DHTR1BOPRM1OPRL1BCHE | |
| SCHEMBL3408690 | 0.79 | OPRL1 (0.49) | HTR1DHTR1BOPRM1OPRL1BCHE | |
| SCHEMBL3431374 | 0.67 | HTR1D (0.39) | HTR1DHTR1BOPRM1OPRL1 | |
| SCHEMBL20883581 | 0.66 | HTR1D (0.57) | HTR1DHTR1B | |
| SCHEMBL27816680 | 0.66 | HTR1D (0.67) | HTR1DHTR1B | |
| SCHEMBL3431375 | 0.66 | OPRM1 (0.40) | HTR1DHTR1BOPRM1OPRL1 | |
| SCHEMBL3410692 | 0.65 | OPRL1 (0.65) | OPRM1OPRL1BCHEACHESIGMAR1 | |
| SCHEMBL27816746 | 0.62 | HTR1D (0.65) | HTR1DHTR1BTACR2 | |
| SCHEMBL23612450 | 0.61 | HTR1D (0.51) | HTR1DHTR1B | |
| SCHEMBL13748790 | 0.61 | HSD17B10 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103552-A1 | SUBSTITUTED INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2009-08-27 | — | — | WO | disclosed |