Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12406559 | 0.83 | HDAC1 (0.40) | HDAC1HDAC6HDAC4HDAC2HDAC11 | |
| SCHEMBL12374015 | 0.83 | HDAC1 (0.40) | HDAC1HDAC6HDAC4HDAC2HDAC11 | |
| SCHEMBL11996734 | 0.68 | HDAC1 (0.38) | HDAC1HDAC6HDAC4HDAC2HDAC11 | |
| SCHEMBL11994458 | 0.68 | HDAC1 (0.34) | HDAC1HDAC6HDAC4HDAC2HDAC11 | |
| SCHEMBL12374018 | 0.67 | DGAT1 (0.41) | HDAC1HDAC6HDAC4HDAC2HDAC11 | |
| SCHEMBL5015454 | 0.65 | MAP4K4 (0.38) | HDAC1HDAC6MTOR | |
| SCHEMBL12374019 | 0.64 | DGAT1 (0.37) | HDAC1HDAC6HDAC4HDAC2HDAC11 | |
| SCHEMBL15489049 | 0.64 | MTOR (0.39) | HDAC1HDAC6MTORKMT2A | |
| SCHEMBL2279669 | 0.64 | HDAC1 (0.40) | HDAC1HDAC6MTORKMT2A | |
| SCHEMBL22530351 | 0.63 | HDAC1 (0.44) | HDAC1HDAC6HDAC4HDAC2HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009105500-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2009-08-27 | — | — | WO | disclosed |