Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948288 | 0.89 | TRPV1 (0.51) | — | |
| SCHEMBL2958203 | 0.89 | MEN1 (0.41) | KDM4ESMN1; SMN2ALDH1A1KMT2ALMNA | |
| SCHEMBL2948294 | 0.89 | TRPV1 (0.51) | — | |
| SCHEMBL2958205 | 0.89 | MEN1 (0.41) | KDM4ESMN1; SMN2ALDH1A1KMT2ALMNA | |
| SCHEMBL2957563 | 0.88 | HDAC3 (0.44) | — | |
| SCHEMBL2948493 | 0.88 | HDAC3 (0.44) | — | |
| SCHEMBL3777528 | 0.86 | TRPV1 (0.42) | SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL3783093 | 0.86 | TRPV1 (0.42) | SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL2958208 | 0.84 | ALDH1A1 (0.43) | KDM4ESMN1; SMN2ALDH1A1KMT2ALMNA | |
| SCHEMBL2959317 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009096701-A2 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | AMOREPACIFIC CORPORATION (KR) | 2009-08-06 | — | — | WO | disclosed |