Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 18/20 | 0.63 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4991320 | 1.00 | CTSK (0.63) | CTSKDGAT2CTSLCTSB | |
| SCHEMBL18193027 | 0.91 | CTSK (0.63) | CTSKCTSLCTSB | |
| SCHEMBL5685378 | 0.90 | CTSK (0.71) | CTSKCTSLCTSB | |
| SCHEMBL4985945 | 0.90 | CTSK (0.71) | CTSKCTSLCTSB | |
| SCHEMBL1379348 | 0.90 | CTSK (0.65) | CTSKDGAT2CTSLCTSB | |
| SCHEMBL4986641 | 0.90 | CTSK (0.65) | CTSKDGAT2CTSLCTSB | |
| SCHEMBL1379625 | 0.87 | CTSK (0.65) | CTSKCTSLCTSB | |
| SCHEMBL4991669 | 0.87 | CTSK (0.65) | CTSKCTSLCTSB | |
| SCHEMBL4990609 | 0.85 | CTSK (0.68) | CTSKCTSLCTSB | |
| SCHEMBL1379169 | 0.85 | CTSK (0.68) | CTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4690319-B2 | — | — | 2011-06-01 | — | — | JP | claimed |
| EP-1644326-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-04-12 | — | — | EP | claimed |
| WO-2005000800-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2005-01-06 | — | — | WO | claimed |
| EP-1644326-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005000800-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2005-01-06 | — | — | WO | disclosed |