⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17727792 | 0.73 | — | — | |
| SCHEMBL12393539 | 0.73 | — | — | |
| SCHEMBL1918865 | 0.73 | — | — | |
| SCHEMBL25868701 | 0.69 | MAPT (0.30) | — | |
| SCHEMBL2390897 | 0.69 | IRAK4 (0.33) | — | |
| SCHEMBL21898663 | 0.69 | — | — | |
| SCHEMBL21623960 | 0.67 | MKNK1 (0.35) | — | |
| SCHEMBL26806847 | 0.66 | ELANE (0.36) | — | |
| SCHEMBL17940784 | 0.66 | GRM5 (0.44) | — | |
| SCHEMBL27598341 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090197913-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR | BAUMANN CHRISTIAN ANDREW | 2009-08-06 | — | — | US | disclosed |
| US-20080051402-A1 | METHOD OF INHIBITING C-KIT KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-28 | — | — | US | disclosed |