Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 17/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260356 | 0.86 | ADRB2 (0.62) | ADRB2ADRB1 | |
| SCHEMBL4255217 | 0.86 | ADRB2 (0.62) | ADRB2ADRB1 | |
| SCHEMBL14422857 | 0.81 | ADRB2 (0.61) | ADRB2ADRB1CASP3CASP6CYP1A2 | |
| SCHEMBL4258384 | 0.80 | ADRB2 (0.73) | ADRB2ADRB1 | |
| SCHEMBL4258388 | 0.80 | ADRB2 (0.73) | ADRB2ADRB1 | |
| SCHEMBL4388964 | 0.78 | ADRB2 (0.57) | ADRB2ADRB1 | |
| SCHEMBL4388971 | 0.78 | ADRB2 (0.57) | ADRB2ADRB1 | |
| SCHEMBL4013045 | 0.77 | ADRB2 (0.69) | ADRB2 | |
| SCHEMBL4013056 | 0.77 | ADRB2 (0.69) | ADRB2 | |
| SCHEMBL4255124 | 0.77 | ADRB2 (0.62) | ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1624868-B9 | \"(2-HYDROXY-2-(4-HYDROXY-3-HYDOXYMETHYLPHENYL)-ETHYLAMINO)- PROPYL]PHENYL DERIVATIVES AS BETA2 AGONISTS | PFIZER LTD (GB) | 2009-08-12 | — | — | EP | disclosed |
| EP-1624868-B1 | \"(2-HYDROXY-2-(4-HYDROXY-3-HYDOXYMETHYLPHENYL)-ETHYLAMINO)- PROPYL]PHENYL DERIVATIVES AS BETA2 AGONISTS | PFIZER LTD (GB) | 2008-11-12 | — | — | EP | disclosed |