Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332296 | 0.91 | PDE5A (0.45) | PDE5AKCNH2MKNK1MKNK2 | |
| SCHEMBL332265 | 0.81 | PDE5A (0.59) | PDE5AKCNH2 | |
| SCHEMBL13756983 | 0.78 | PDE5A (0.52) | PDE5AKCNH2 | |
| SCHEMBL4045404 | 0.76 | PDE5A (0.47) | PDE5AKCNH2 | |
| SCHEMBL4037116 | 0.74 | PDE5A (0.47) | PDE5AKCNH2 | |
| SCHEMBL331941 | 0.74 | PDE5A (0.68) | PDE5AKCNH2 | |
| SCHEMBL12768916 | 0.72 | PDE5A (0.48) | PDE5AKCNH2 | |
| SCHEMBL10286218 | 0.71 | HTR2C (0.38) | PDE5A | |
| SCHEMBL331899 | 0.70 | PDE5A (0.58) | PDE5AKCNH2 | |
| SCHEMBL8295331 | 0.70 | PDE5A (0.56) | PDE5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572799-B2 | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors | PFIZER INC (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572799-B2 | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors | PFIZER INC (US) | 2009-08-11 | — | — | US | disclosed |