Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1582066 | 1.00 | GCK (0.67) | GCKMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL1581520 | 0.99 | GCK (0.65) | GCKMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL13757051 | 0.99 | GCK (0.65) | GCKMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL12720684 | 0.99 | GCK (0.65) | GCKMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL1582051 | 0.92 | GCK (0.57) | GCKMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL13757073 | 0.92 | GCK (0.57) | GCKMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL9072594 | 0.84 | RAB9A (0.50) | GCKMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL1581947 | 0.84 | RAB9A (0.52) | GCKMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL12720782 | 0.83 | RAB9A (0.51) | GCKMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL2666188 | 0.82 | GCK (0.82) | GCKMEN1KMT2ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576108-B2 | Substituted arylcyclopropylacetamides as glucokinase activators | ELI LILLY AND COMPANY (US) | 2009-08-18 | — | — | US | disclosed |