Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.38 |
| ▸ | FPR1 | P21462 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480896 | 0.80 | GRIN1 (0.53) | KMT2AMEN1GPR17GRIN1 | |
| SCHEMBL8337673 | 0.70 | MEN1 (0.63) | KMT2AMEN1 | |
| SCHEMBL4352566 | 0.67 | GRIN1 (0.55) | KMT2AMEN1GPR17GRIN1 | |
| SCHEMBL11670709 | 0.64 | TSHR (0.71) | KMT2AMEN1TSHRALDH1A1HTT | |
| SCHEMBL1006444 | 0.63 | HTT (0.71) | KMT2AMEN1TSHRALDH1A1HTT | |
| SCHEMBL14427603 | 0.62 | MEN1 (0.66) | KMT2AMEN1TSHRALDH1A1HTT | |
| SCHEMBL16508380 | 0.61 | TSHR (0.52) | KMT2AMEN1TSHRALDH1A1HTT | |
| SCHEMBL10794042 | 0.61 | ALDH1A1 (0.66) | KMT2AMEN1TSHRALDH1A1HTT | |
| SCHEMBL3454665 | 0.61 | MEN1 (0.76) | KMT2AMEN1TSHRALDH1A1HTT | |
| SCHEMBL9452355 | 0.61 | MEN1 (0.51) | KMT2AMEN1TSHRGRIN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501797-B1 | 3-(SUBSTITUTED AMINO)-1H-INDOLE-2-CARBOXYLIC ACID ESTER AND 3-(SUBSTITUTED AMINO)-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ESTER DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS | AVENTIS PHARMA INC (US) | 2009-08-05 | — | — | EP | disclosed |