Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 5/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | AHCY | P23526 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13759294 | 0.81 | CDK1 (0.53) | CDK1DYRK1AADORA2AADORA1CCNB1 | |
| SCHEMBL13764820 | 0.81 | CDK1 (0.45) | CDK1DYRK1AADORA2AADORA1CCNB1 | |
| SCHEMBL15457576 | 0.81 | AHCY (0.49) | CDK1DYRK1AADORA2AADORA1CCNB1 | |
| SCHEMBL18409182 | 0.79 | CDK1 (0.42) | CDK1DYRK1AADORA2AADORA1CCNB1 | |
| SCHEMBL12344290 | 0.76 | DYRK1A (0.40) | CDK1DYRK1AADORA2AADORA1CCNB1 | |
| SCHEMBL18409422 | 0.75 | CDK1 (0.42) | CDK1DYRK1AADORA2AADORA1CCNB1 | |
| SCHEMBL2766667 | 0.72 | DYRK1A (0.37) | CDK1DYRK1AADORA2AADORA1CCNB1 | |
| SCHEMBL6877790 | 0.71 | KDM4E (0.53) | CDK1ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL18520389 | 0.69 | ADORA2A (0.43) | CDK1DYRK1AADORA2AADORA1CCNB1 | |
| SCHEMBL18398413 | 0.69 | ADORA2A (0.46) | DYRK1AADORA2AADORA1TLR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642602-B2 | Method of inhibiting fibrogenesis and treating fibrotic disease | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-7557211-B2 | 8H-imidazo[4,5-D]thiazolo[4,5-B]pyridine based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-07-07 | — | — | US | disclosed |
| US-7557211-B2 | 8H-imidazo[4,5-D]thiazolo[4,5-B]pyridine based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-07-07 | — | — | US | disclosed |