Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14412518 | 0.89 | LMNA (0.41) | LMNASMN1; SMN2HTTNPY5RGBA1 | |
| SCHEMBL13759304 | 0.87 | GBA1 (0.46) | LMNASMN1; SMN2HTTNPY5RGBA1 | |
| SCHEMBL14413078 | 0.80 | LMNA (0.51) | LMNASMN1; SMN2HTTNPY5RGBA1 | |
| SCHEMBL428798 | 0.80 | MAPT (0.43) | LMNASMN1; SMN2GBA1MEN1KMT2A | |
| SCHEMBL429470 | 0.80 | GBA1 (0.49) | LMNASMN1; SMN2HTTGBA1MEN1 | |
| SCHEMBL427561 | 0.79 | GBA1 (0.49) | LMNASMN1; SMN2HTTGBA1MEN1 | |
| SCHEMBL430964 | 0.78 | MAPT (0.46) | LMNASMN1; SMN2HTTGBA1MEN1 | |
| SCHEMBL13759199 | 0.76 | SLC29A1 (0.51) | LMNASMN1; SMN2HTTGBA1MEN1 | |
| SCHEMBL13759290 | 0.74 | MAPK1 (0.51) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL14412728 | 0.74 | LMNA (0.44) | LMNASMN1; SMN2HTTNPY5RGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100406-A2 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-13 | — | — | WO | disclosed |