Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060239 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL14156210 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL13760873 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL14156234 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL8047901 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL12778184 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL14163095 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL12778181 | 0.76 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL8060277 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL13760878 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557137-B2 | Gamma-lactams as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-07-07 | — | — | US | disclosed |
| US-20070265331-A1 | Novel gamma-lactams as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265331-A1 | Novel gamma-lactams as beta-secretase inhibitors | BACE1, APP, BACE2 | SMN1; SMN2 1825/4885ALDH1A1 2416/4885HPGD 2418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.