Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP3 | P08254 | 4/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14156234 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2MMP1MMP2MMP3CTSS | |
| SCHEMBL13760873 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2MMP1MMP2MMP3CTSS | |
| SCHEMBL8060239 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2CTSSCTSKALDH1A1THRB | |
| SCHEMBL13760872 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2CTSSCTSKALDH1A1THRB | |
| SCHEMBL14156210 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2CTSSCTSKALDH1A1THRB | |
| SCHEMBL12778181 | 0.81 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL14163094 | 0.81 | SMN1; SMN2 (0.38) | SMN1; SMN2MMP1MMP2MMP3ALDH1A1 | |
| SCHEMBL14388405 | 0.81 | SMN1; SMN2 (0.38) | SMN1; SMN2MMP1MMP2MMP3ALDH1A1 | |
| SCHEMBL2083933 | 0.76 | CTSL (0.42) | SMN1; SMN2PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL12778184 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1PRSS1CTSGCTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080153868-A1 | Substituted Tetrahydroisoquinolines as Beta-secretase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153868-A1 | Substituted Tetrahydroisoquinolines as Beta-secretase Inhibitors | BACE1, APP, BACE2 | SMN1; SMN2 574/4885MMP1 3059/4885MMP2 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.