Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334940 | 0.93 | GSK3B (0.56) | GSK3BCDK1CDK2CDC7AURKB | |
| SCHEMBL1376173 | 0.92 | GSK3B (0.57) | GSK3BCDK1CDK2CDC7AURKB | |
| SCHEMBL6528308 | 0.90 | GSK3B (0.50) | GSK3BCDK1CDK2CDC7ACHE | |
| SCHEMBL6531233 | 0.90 | GSK3B (0.57) | GSK3BCDK1CDK2CDC7AURKB | |
| SCHEMBL2337764 | 0.89 | GSK3B (0.60) | GSK3BCDK1CDK2AURKBAPP | |
| SCHEMBL1377267 | 0.88 | GSK3B (0.59) | GSK3BCDK1CDK2CDC7ACHE | |
| SCHEMBL2338648 | 0.83 | GSK3B (0.58) | GSK3BCDK1CDK2CDC7APP | |
| SCHEMBL1375621 | 0.80 | GSK3B (0.64) | GSK3BCDK1CDK2CDC7APP | |
| SCHEMBL1377239 | 0.78 | GSK3B (0.54) | GSK3BCDK1CDK2CDC7ACHE | |
| SCHEMBL1378947 | 0.77 | GSK3B (0.70) | GSK3BCDK1CDK2CDC7ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4764168-B2 | — | — | 2011-08-31 | — | — | JP | claimed |
| EP-1572200-A1 | AMINOINDAZOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-09-14 | — | — | EP | claimed |
| WO-2004062662-A1 | AMINOINDAZOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-07-29 | — | — | WO | claimed |