Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3876017 | 0.95 | TRPV1 (0.50) | TRPV1MTORHSD11B1 | |
| SCHEMBL13761519 | 0.95 | TRPV1 (0.50) | TRPV1MTORHSD11B1 | |
| SCHEMBL3881501 | 0.92 | TRPV1 (0.47) | TRPV1MTORMAP3K12DYRK1ACHRM4 | |
| SCHEMBL13761534 | 0.92 | TRPV1 (0.47) | TRPV1MTORMAP3K12DYRK1ACHRM4 | |
| SCHEMBL3890908 | 0.92 | TRPV1 (0.50) | TRPV1MTORMAP3K12HSD11B1 | |
| SCHEMBL3882205 | 0.90 | TRPV1 (0.43) | TRPV1MAP3K12SYK | |
| SCHEMBL13761531 | 0.90 | TRPV1 (0.43) | TRPV1MAP3K12SYK | |
| SCHEMBL3880813 | 0.89 | TRPV1 (0.44) | TRPV1MTORSYK | |
| SCHEMBL3877270 | 0.88 | TRPV1 (0.49) | TRPV1MTORMAP3K12 | |
| SCHEMBL3879150 | 0.87 | TRPV1 (0.47) | TRPV1MAP3K12CHRM4HSD11B1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |