Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.50 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877270 | 0.93 | TRPV1 (0.49) | TRPV1MTORMAP3K12ATRATRIP | |
| SCHEMBL13761502 | 0.92 | TRPV1 (0.49) | TRPV1MTORHSD11B1MAP3K12 | |
| SCHEMBL13761519 | 0.91 | TRPV1 (0.50) | TRPV1MTORHSD11B1ATRATRIP | |
| SCHEMBL3876017 | 0.91 | TRPV1 (0.50) | TRPV1MTORHSD11B1ATRATRIP | |
| SCHEMBL3880267 | 0.91 | TRPV1 (0.48) | TRPV1MTORHSD11B1 | |
| SCHEMBL3877036 | 0.90 | TRPV1 (0.46) | TRPV1MTORHSD11B1MAP3K12ATR | |
| SCHEMBL3880528 | 0.90 | TRPV1 (0.44) | TRPV1HSD11B1 | |
| SCHEMBL3878601 | 0.87 | TRPV1 (0.49) | TRPV1HSD11B1 | |
| SCHEMBL3887544 | 0.87 | TRPV1 (0.49) | TRPV1HSD11B1 | |
| SCHEMBL3884072 | 0.87 | TRPV1 (0.49) | TRPV1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |