Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.52 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.52 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11832198 | 0.87 | DYRK1A (0.50) | LDHACSNK1DCSNK1G2MAP3K5DYRK1A | |
| SCHEMBL5683714 | 0.85 | DYRK1A (0.68) | LDHACSNK1DDYRK1ACYP2D6ACP1 | |
| SCHEMBL14648829 | 0.85 | CSNK1D (0.51) | CSNK1DCSNK1G2MAP3K5DYRK1ACYP2D6 | |
| SCHEMBL7028444 | 0.85 | NPC1 (0.59) | CSNK1DCSNK1G2MAP3K5DYRK1AKCNH2 | |
| SCHEMBL10189655 | 0.83 | CSNK1D (0.49) | CSNK1DCSNK1G2MAP3K5DYRK1ACYP2D6 | |
| SCHEMBL10189473 | 0.83 | CSNK1D (0.49) | CSNK1DCSNK1G2MAP3K5DYRK1ACYP2D6 | |
| SCHEMBL179517 | 0.81 | MAP3K5 (0.60) | LDHACSNK1DMAP3K5DYRK1ACYP2D6 | |
| SCHEMBL12829397 | 0.80 | NPC1 (0.68) | CSNK1DCSNK1G2MAP3K5DYRK1AACP1 | |
| SCHEMBL179544 | 0.80 | DYRK1A (0.78) | LDHACSNK1DMAP3K5DYRK1ANPC1 | |
| SCHEMBL13508876 | 0.80 | NPC1 (0.63) | CSNK1DCSNK1G2MAP3K5DYRK1ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557110-B2 | MAPKAP-K2; inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth; 5-[(trans-4-aminocyclohexyl)amino]-3-fluoro-6-methyl(pyrazolo[1,5-a]pyri- midin-7-yl)}(4-iodophenyl)amine | TEIJIN PHARMA LIMITED (JP) | 2009-07-07 | — | — | US | disclosed |