Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13762154 | 0.83 | ALDH1A1 (0.57) | LMNAALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL14113318 | 0.81 | NPC1 (1.00) | NPC1LMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13762162 | 0.80 | LDHA (0.52) | NPC1LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL14648829 | 0.79 | CSNK1D (0.51) | NPC1LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7028444 | 0.79 | NPC1 (0.59) | NPC1LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL14451223 | 0.77 | NPC1 (0.68) | NPC1LMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL179544 | 0.77 | DYRK1A (0.78) | NPC1SMN1; SMN2MAP3K5RAB9ADYRK1A | |
| SCHEMBL10189655 | 0.77 | CSNK1D (0.49) | NPC1LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL10189473 | 0.77 | CSNK1D (0.49) | MAP3K5DYRK1ACSNK1DCSNK1G2ACP1 | |
| SCHEMBL14509001 | 0.76 | NPC1 (0.66) | NPC1LMNAALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110077268-A1 | KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE LLC | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077268-A1 | KINASE INHIBITORS AND METHODS OF USE | MAP3K20, MAP3K1, PDPK1 | NPC1 2078/4885LMNA 2831/4885ALDH1A1 4739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.