Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.71 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 3/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30151910 | 0.88 | HTT (0.65) | HTTIRAK4LMNAMAPTKMT2A | |
| SCHEMBL15163056 | 0.88 | HTT (0.65) | HTTIRAK4LMNAMAPTKMT2A | |
| SCHEMBL30625937 | 0.85 | HTT (0.54) | HTTIRAK4LMNAMAPTKMT2A | |
| SCHEMBL17799584 | 0.85 | HTT (0.53) | HTTIRAK4LMNAMAPTKMT2A | |
| SCHEMBL27725562 | 0.85 | HTT (0.54) | HTTIRAK4LMNAMAPTKMT2A | |
| SCHEMBL7492316 | 0.84 | HTT (0.59) | HTTIRAK4LMNAMAPTKMT2A | |
| SCHEMBL477006 | 0.84 | ALDH1A1 (0.59) | HTTLMNAKMT2AMEN1KDM4E | |
| SCHEMBL3339926 | 0.84 | ABCB1 (0.64) | HTTLMNAMAPTKMT2AMEN1 | |
| Bicarbonate SCHEMBL236893 | 0.83 | ALDH1A1 (0.57) | HTTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL17799583 | 0.83 | ALDH1A1 (0.57) | HTTKMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3837262-A1 | N-CYANO-7-AZANORBORNANE DERIVATIVES AND USES THEREOF | Amgen Inc. (US) | 2021-06-23 | — | — | EP | disclosed |
| WO-2020036940-A1 | N-CYANO-7-AZANORBORNANE DERIVATIVES AND USES THEREOF | AMGEN INC. (US) | 2020-02-20 | — | — | WO | disclosed |
| CN-103788012-B | A kind of method of preparing Febuxostat | Peking Founder Group Co., Ltd. (CN) | 2016-05-25 | — | — | CN | disclosed |
| CN-103788010-A | Febuxostat intermediate and preparation method thereof | UNIV PEKING FOUNDER GROUP CO | 2014-05-14 | — | — | CN | disclosed |
| CN-103788011-A | Febuxostat intermediate and preparation method thereof | UNIV PEKING FOUNDER GROUP CO | 2014-05-14 | — | — | CN | disclosed |
| US-7556918-B2 | Color photographic films comprising support having color developable light sensitive silver halide emulsion layers and color dye-forming couplers, used for high speed print reproduction; storage stability | FUJIFILM CORPORATION (JP) | 2009-07-07 | — | — | US | disclosed |
| US-7425408-B2 | Silver halide color photographic light-sensitive material | FUJIFILM CORPORATION (JP) | 2008-09-16 | — | — | US | disclosed |
| US-20080113305-A1 | SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL | FUJIFILM CORPORATION | 2008-05-15 | — | — | US | disclosed |
| US-7196194-B2 | Dye-forming coupler, silver halide photographic light-sensitive material and azomethine dye compound | FUJI PHOTO FILM CO., LTD (JP) | 2007-03-27 | — | — | US | disclosed |
| US-20070054224-A1 | Silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. | 2007-03-08 | — | — | US | disclosed |
| US-7183044-B2 | Silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 2007-02-27 | — | — | US | disclosed |