Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 17/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3751523 | 0.91 | CRHR1 (0.51) | CRHR1KCNK3 | |
| SCHEMBL3759019 | 0.81 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL3753684 | 0.81 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL13058203 | 0.80 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL3753482 | 0.77 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL3746111 | 0.73 | CRHR1 (0.60) | CRHR1ADORA2A | |
| SCHEMBL3748752 | 0.72 | CRHR1 (0.68) | CRHR1 | |
| SCHEMBL3752457 | 0.72 | CRHR1 (0.68) | CRHR1 | |
| SCHEMBL3753293 | 0.71 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL3748326 | 0.71 | CRHR1 (0.61) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |