Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 20/20 | 0.59 |
| ▸ | PPARA | Q07869 | 11/20 | 0.59 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1376944 | 0.91 | PPARD (0.53) | PPARDPPARAPPARG | |
| SCHEMBL2426059 | 0.91 | PPARD (0.49) | PPARDPPARA | |
| SCHEMBL1380117 | 0.88 | PPARD (0.61) | PPARDPPARAPPARG | |
| SCHEMBL1379823 | 0.86 | PPARD (0.59) | PPARDPPARAPPARG | |
| SCHEMBL2424272 | 0.82 | PPARD (0.43) | PPARDPPARAPPARG | |
| SCHEMBL1376252 | 0.81 | PPARD (0.55) | PPARDPPARAPPARG | |
| SCHEMBL1376739 | 0.81 | PPARD (0.54) | PPARDPPARAPPARG | |
| SCHEMBL5904770 | 0.80 | PPARD (0.62) | PPARDPPARAPPARG | |
| SCHEMBL1379391 | 0.79 | PPARD (0.63) | PPARDPPARAPPARG | |
| SCHEMBL1380038 | 0.79 | PPARD (0.49) | PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237640-A1 | PYRAZOLE PHENYL DERIVATIVES | ACKERMANN JEAN | 2011-09-29 | — | — | US | claimed |
| JP-4733692-B2 | — | — | 2011-07-27 | — | — | JP | claimed |
| US-20100035953-A1 | Pyrazole Phenyl Derivatives | ACKERMANN JEAN | 2010-02-11 | — | — | US | claimed |
| EP-1742923-B1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | claimed |
| EP-1742923-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105754-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | claimed |
| US-20050245589-A1 | Pyrazole phenyl derivatives | HOFFMANN-LA ROCHE INC. | 2005-11-03 | — | — | US | claimed |
| US-20110237640-A1 | PYRAZOLE PHENYL DERIVATIVES | ACKERMANN JEAN | 2011-09-29 | — | — | US | disclosed |
| US-20100035953-A1 | Pyrazole Phenyl Derivatives | ACKERMANN JEAN | 2010-02-11 | — | — | US | disclosed |
| EP-1742923-B1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | disclosed |
| EP-1742923-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005105754-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | disclosed |
| US-20050245589-A1 | Pyrazole phenyl derivatives | HOFFMANN-LA ROCHE INC. | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035953-A1 | Pyrazole Phenyl Derivatives | PPARD, PPARG, PPARA | PPARD 1/4885PPARA 3/4885PPARG 2/4885 |
| US-20050245589-A1 | Pyrazole phenyl derivatives | PPARD, PPARG, PPARA | PPARD 1/4885PPARA 3/4885PPARG 2/4885 |
| US-20110237640-A1 | PYRAZOLE PHENYL DERIVATIVES | PPARD, PPARG, PPARA | PPARD 1/4885PPARA 3/4885PPARG 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.