Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 5/20 | 0.49 |
| ▸ | GSK3B | P49841 | 5/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 8/20 | 0.46 |
| ▸ | CASP1 | P29466 | 6/20 | 0.46 |
| ▸ | CASP7 | P55210 | 5/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | HBB | P68871 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13763949 | 0.88 | GSK3A (0.53) | GSK3AGSK3BAURKACYP1A2CYP2C9 | |
| SCHEMBL13763963 | 0.88 | GSK3A (0.53) | GSK3AGSK3BAURKACYP1A2CYP2C9 | |
| SCHEMBL13763965 | 0.87 | GSK3A (0.61) | GSK3AGSK3BSYKAURKACYP1A2 | |
| SCHEMBL13303682 | 0.86 | GSK3A (0.67) | GSK3AGSK3BSYKAURKACYP1A2 | |
| SCHEMBL13303696 | 0.85 | GSK3A (0.69) | GSK3AGSK3BAURKACYP1A2CYP2C9 | |
| SCHEMBL13764062 | 0.84 | GSK3A (0.55) | GSK3AGSK3BSYKAURKACYP1A2 | |
| SCHEMBL13764055 | 0.84 | GSK3A (0.54) | GSK3AGSK3BAURKACYP1A2CYP2C9 | |
| SCHEMBL13763966 | 0.83 | GSK3A (0.51) | GSK3AGSK3BAURKACYP1A2CYP2C9 | |
| SCHEMBL8297191 | 0.83 | GSK3A (0.54) | GSK3AGSK3BSYKAURKACYP1A2 | |
| SCHEMBL8296516 | 0.83 | GSK3A (0.55) | GSK3AGSK3BSYKAURKAEIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560458-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-07-14 | — | — | US | disclosed |
| US-7560458-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-07-14 | — | — | US | disclosed |
| US-20090036471-A1 | Triazolopyrimidine Derivatives As Glycogen Synthase Kinase 3 Inhibitors | EDGARD EDDY JEAN | 2009-02-05 | — | — | US | disclosed |
| US-20090036471-A1 | Triazolopyrimidine Derivatives As Glycogen Synthase Kinase 3 Inhibitors | EDGARD EDDY JEAN | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036471-A1 | Triazolopyrimidine Derivatives As Glycogen Synthase Kinase 3 Inhibitors | GSK3B, GSK3A, GYS2 | GSK3A 2/4885GSK3B 1/4885SYK 340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.