GYS2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL30925714	0.85	1/20
SCHEMBL12181490	0.69	1/20
SCHEMBL12181496	0.69	1/20
SCHEMBL24433072	0.69	1/20
SCHEMBL24433073	0.69	1/20
SCHEMBL29649785	0.69	1/20
SCHEMBL29649857	0.69	1/20
SCHEMBL12474858	0.64	1/20
SCHEMBL15163880	0.64	1/20
SCHEMBL15163884	0.64	1/20
SCHEMBL29485172	0.62	1/20
SCHEMBL13487367	0.62	1/20
SCHEMBL13637888	0.62	1/20
SCHEMBL13523697	0.60	1/20
SCHEMBL13523646	0.59	1/20
SCHEMBL29934465	0.58	1/20
SCHEMBL12181559	0.58	1/20
SCHEMBL20106662	0.58	1/20
SCHEMBL13629645	0.58	1/20
SCHEMBL29934649	0.57	1/20

Clinical trials — most relevant to GYS2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of Triheptanoin on Fatty Acid Oxidation and Exercise Tolerance in Patients With Glycogenoses	PHASE2	COMPLETED
Effects of Dual-Source Carbohydrate Intake and Liver Glycogen Repletion After Overnight Fasting.	nan	NOT_YET_RECRUITING
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging	nan	COMPLETED
Effect of Meal Timing in T2D on Hepatocytes SRIT1 and Clock Genes	nan	UNKNOWN
Liver Glycogen Dynamics	nan	COMPLETED
Effect of High Carbohydrate vs. Low Carbohydrate Diet in Type 2 Diabetes	nan	COMPLETED
Impact of Physical Activity on Blood Glucose Stability and Energy Stores in Individuals With Type 1 Diabetes	nan	COMPLETED
Hepatic Glycogen and Fat Oxidation	nan	COMPLETED
The Role of Sugars in Fat Accumulation in the Liver	nan	RECRUITING
Growth Hormone Use in Adolescents and Adults With Cystic Fibrosis	nan	WITHDRAWN
The Study of HIV Protease Inhibitors and Their Effects on Glucose Metabolism	nan	COMPLETED
The Effects of Citric and Malic Acid Found in Pomegranate Juice on Glycaemic Response to White Bread.	nan	COMPLETED
Effect of a Beverage Comprised of Compounds From Olives on Post-prandial Blood Glucose Responses in Healthy Volunteers	nan	COMPLETED
Steviol Glycoside for Use in Restoring Muscle Glycogen by Increasing the Rate of Glycogen Re-synthesis in Muscles	nan	UNKNOWN
Effects of Polyphenols Found in Pomegranate Juice on Postprandial Blood Glucose in Vivo	nan	COMPLETED
Moderately Carbohydrate-restricted Diet to Treat NAFLD in Adolescents	nan	ACTIVE_NOT_RECRUITING
Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo.	nan	COMPLETED
Effect of Glycogen Replenishment on Time Trial Performance Following a Glycogen Lowering Exercise	nan	UNKNOWN
Non Invasive Assessment of Liver Glycogen Kinetics and ATP Synthesis in Type1 Diabetics	nan	COMPLETED
Effect of an Polyphenolic Beverage in Healthy Volunteers	nan	ACTIVE_NOT_RECRUITING
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females	nan	COMPLETED
Short Term Intermittent Fasting and Insulin Resistance	nan	UNKNOWN
Evaluation of Glycemic Impact on Fetal Liver Length and Volume by Ultrasound in Pregnancy	nan	NOT_YET_RECRUITING
Galactose Mediated Glycogen Resynthesis	nan	COMPLETED
A Study to Determine the Safety and Efficacy of Oligopin® on Metabolic Risk Factors in Subjects With Metabolic Syndrome	nan	UNKNOWN
Does Insulin Requirement Post Cardiac Surgery Predicts The Risk Of Developing Diabetes	nan	UNKNOWN
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Effects of Carbohydrase-inhibiting Polyphenols on Glycaemic Response in Vivo	nan	COMPLETED
Prevention of Hypoglycaemia by Oral 40% Destrogel	nan	COMPLETED
Lipid and Glycogen Metabolism in Patients With Impaired Glucose Tolerance and Calcium Sensing Receptor Mutations	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a GYS2 binder may also engage these)

Protein	Name	Similarity
Q8VCB3	—	1.000	Q8VCB3 →
P17625	—	1.000	P17625 →
Q8MJ26	—	1.000	Q8MJ26 →
GYS1	Glycogen [starch] synthase, muscle	1.000	landscape →
A2RRU1	—	1.000	A2RRU1 →
P27472	—	1.000	P27472 →
O93869	—	1.000	O93869 →
Q9Z1E4	—	1.000	Q9Z1E4 →
J9VTK7	—	1.000	J9VTK7 →
Q9U2D9	—	1.000	Q9U2D9 →
P13834	—	1.000	P13834 →
Q5R9H0	—	1.000	Q5R9H0 →
P23337	—	0.999	P23337 →
Q9VFC8	—	0.997	Q9VFC8 →
A7MB78	—	0.995	A7MB78 →
B4NBB0	—	0.993	B4NBB0 →
O84250	—	0.991	O84250 →
P32811	—	0.991	P32811 →
Q6DW75	—	0.991	Q6DW75 →
P0AC87	—	0.991	P0AC87 →
Q6DW73	—	0.991	Q6DW73 →
Q9PKE6	—	0.990	Q9PKE6 →
Q2WF59	—	0.990	Q2WF59 →
F4J8C6	—	0.990	F4J8C6 →
B0XDC4	—	0.990	B0XDC4 →
P45180	—	0.990	P45180 →
Q5XHF8	—	0.990	Q5XHF8 →
Q9UUI7	—	0.989	Q9UUI7 →
B3M383	—	0.989	B3M383 →
Q9STV0	—	0.989	Q9STV0 →