Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.78 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.78 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13764336 | 0.88 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL1105146 | 0.88 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL25561859 | 0.88 | ROCK2 (1.00) | ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL1096293 | 0.86 | ROCK2 (0.97) | ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL1096289 | 0.86 | ROCK2 (0.97) | ROCK2ROCK1 | |
| SCHEMBL1105160 | 0.85 | ROCK2 (0.60) | ROCK2ROCK1MYLK4 | |
| SCHEMBL14562498 | 0.85 | ROCK2 (0.60) | ROCK2ROCK1MYLK4 | |
| SCHEMBL19886419 | 0.85 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| SCHEMBL14642211 | 0.83 | ROCK2 (0.67) | ROCK2ROCK1MYLK4 | |
| SCHEMBL1123543 | 0.82 | ROCK2 (0.90) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546239-B1 | 6-AMINO ISOQUINOLINS COMPOUNDS AND METHODS FOR MAKING THE SAME | AERIE PHARMACEUTICALS INC (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8871757-B2 | 6-and 7-amino isoquinoline compounds and methods for making and using the same | AERIE PHARMACEUTICALS, INC. (US) | 2014-10-28 | — | — | US | disclosed |
| EP-2546239-A1 | 6-AMINO ISOQUINOLINS COMPOUNDS AND METHODS FOR MAKING THE SAME | AERIE PHARMACEUTICALS, INC. (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2009091898-A2 | 6-AND 7-AMINO ISOQUINOLINE COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | AERIE PHARMACEUTICALS, INC. (US) | 2009-07-23 | — | — | WO | disclosed |