Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748005 | 0.93 | CRHR1 (0.54) | CRHR1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13058115 | 0.85 | CRHR1 (0.60) | CRHR1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3751474 | 0.79 | CRHR1 (0.61) | CRHR1KDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3746504 | 0.79 | CRHR1 (0.55) | CRHR1MAPTKMT2A | |
| SCHEMBL3750765 | 0.79 | CRHR1 (0.48) | CRHR1KDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3756594 | 0.76 | CRHR1 (0.49) | CRHR1OPRM1OPRD1OPRK1 | |
| SCHEMBL3665947 | 0.76 | CRHR1 (0.51) | CRHR1OPRM1OPRD1OPRK1 | |
| SCHEMBL3750813 | 0.74 | CRHR1 (0.75) | CRHR1TP53 | |
| SCHEMBL3746090 | 0.74 | CRHR1 (0.51) | CRHR1KDM4EALDH1A1MAPTGAA | |
| SCHEMBL3751351 | 0.73 | CRHR1 (0.62) | CRHR1KDM4ESMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |