Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL761858 | 1.00 | KMT2A (0.45) | KMT2AMAPK1MAPTHSD11B1P2RX7 | |
| SCHEMBL2242605 | 1.00 | KMT2A (0.45) | KMT2AMAPK1MAPTHSD11B1P2RX7 | |
| SCHEMBL19308424 | 0.87 | HSD11B1 (0.40) | KMT2AHSD11B1ATM | |
| SCHEMBL16491324 | 0.87 | HSD11B1 (0.40) | KMT2AHSD11B1ATM | |
| SCHEMBL3974883 | 0.86 | KMT2A (0.45) | KMT2AMAPK1MAPTHSD11B1CYP2D6 | |
| SCHEMBL2761882 | 0.83 | KMT2A (0.49) | KMT2AMAPK1MAPTHSD11B1P2RX7 | |
| SCHEMBL2241415 | 0.83 | KMT2A (0.49) | KMT2AMAPK1MAPTHSD11B1P2RX7 | |
| SCHEMBL2670214 | 0.82 | KMT2A (0.43) | KMT2AMAPK1MAPTHSD11B1P2RX7 | |
| SCHEMBL2670528 | 0.82 | KMT2A (0.43) | KMT2AMAPK1MAPTHSD11B1P2RX7 | |
| SCHEMBL14319760 | 0.82 | KMT2A (0.43) | KMT2AMAPK1MAPTHSD11B1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7563805-B2 | 7-[3-Amino-3,4-dimethylpyrrolidine-1-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid: quinoline bactericide; broad spectrum, strong antibacterial activity for Grampositive/-negative including multiple resistant cocci; side effect reductcion; drug design | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-07-21 | — | — | US | disclosed |