Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927643 | 0.90 | GAA (0.37) | TP53MAPTTSHRSMN1; SMN2LMNA | |
| SCHEMBL2929962 | 0.86 | SMN1; SMN2 (0.47) | TP53MAPTALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL2931023 | 0.82 | GAA (0.39) | TP53MAPTTSHRSMN1; SMN2LMNA | |
| SCHEMBL2929535 | 0.77 | SMN1; SMN2 (0.50) | TP53MAPTALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL2930071 | 0.75 | ALDH1A1 (0.41) | MAPTALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL2930507 | 0.73 | MAP2 (0.43) | TP53MAPTALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL2927462 | 0.73 | TP53 (0.44) | TP53MAPTALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4019073 | 0.72 | GAA (0.48) | TP53MAPTALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL2931274 | 0.72 | MAP2 (0.44) | MAPTALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL2927095 | 0.71 | ALDH1A1 (0.44) | TP53MAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186871-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2009-07-23 | — | — | US | disclosed |
| US-7560546-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186871-A1 | Tyrosine kinase inhibitors | ABL1, JAK2, ERBB2 | TP53 523/4885MAPT 2505/4885ALDH1A1 2434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.