Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657617 | 0.86 | RIPK1 (0.64) | RIPK1ESR2NR1H2MAPK1USP2 | |
| SCHEMBL856288 | 0.85 | RIPK1 (0.48) | RIPK1ESR2NR1H2MAPK1USP2 | |
| SCHEMBL30405260 | 0.85 | RIPK1 (0.48) | RIPK1ESR2NR1H2MAPK1USP2 | |
| SCHEMBL2727759 | 0.84 | RIPK1 (0.47) | RIPK1ESR2NR1H2MAPK1USP2 | |
| SCHEMBL3762084 | 0.84 | RIPK1 (0.47) | RIPK1ESR2NR1H2MAPK1USP2 | |
| SCHEMBL22993336 | 0.83 | RIPK1 (0.49) | RIPK1ESR2NR1H2MAPK1USP2 | |
| SCHEMBL3761090 | 0.83 | RIPK1 (0.47) | RIPK1ESR2NR1H2MAPK1USP2 | |
| SCHEMBL855880 | 0.83 | RIPK1 (0.47) | RIPK1ESR2NR1H2MAPK1USP2 | |
| SCHEMBL29388824 | 0.83 | RIPK1 (0.49) | RIPK1ESR2NR1H2MAPK1USP2 | |
| SCHEMBL2987643 | 0.82 | RIPK1 (0.55) | RIPK1ESR2NR1H2MAPK1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080725-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP) | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |