Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 20/20 | 0.61 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13360884 | 0.94 | PDGFRB (0.59) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL13360876 | 0.87 | PDGFRB (0.66) | PDGFRBKITFLT3 | |
| SCHEMBL13105997 | 0.78 | PDGFRB (0.64) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL13330456 | 0.76 | PDGFRB (1.00) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL13360952 | 0.76 | PDGFRB (0.52) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL13330467 | 0.70 | PDGFRB (0.95) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL13330468 | 0.69 | PDGFRB (0.88) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL13773428 | 0.68 | PDGFRB (0.58) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL13932716 | 0.68 | SRC (0.39) | FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL2592017 | 0.67 | PDGFRB (1.00) | PDGFRBKITFGFR1PDGFRAFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560461-B2 | Quinazoline derivatives as kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-07-14 | — | — | US | disclosed |