SCHEMBL2592017

SCHEMBL2592017

COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 20/20 1.00
PDGFRA P16234 2/20 1.00
KIT P10721 1/20 1.00
FGFR1 P11362 1/20 1.00
FGFR2 P21802 1/20 1.00
FGFR4 P22455 1/20 1.00
FGFR3 P22607 1/20 1.00
FLT3 P36888 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2923829 0.96 PDGFRB (1.00) PDGFRBPDGFRAKITFGFR1FGFR2
SCHEMBL2921252 0.95 PDGFRB (1.00) PDGFRBPDGFRAKITFGFR1FGFR2
SCHEMBL2921098 0.95 PDGFRB (1.00) PDGFRBPDGFRAKITFGFR1FGFR2
SCHEMBL2914141 0.94 PDGFRB (1.00) PDGFRBPDGFRAKITFGFR1FGFR2
SCHEMBL2923097 0.94 PDGFRB (1.00) PDGFRBPDGFRAKITFGFR1FGFR2
SCHEMBL2922440 0.94 PDGFRB (0.89) PDGFRBPDGFRAKITFGFR1FGFR2
SCHEMBL2923657 0.94 PDGFRB (1.00) PDGFRBPDGFRAKITFGFR1FGFR2
SCHEMBL13330456 0.93 PDGFRB (1.00) PDGFRBPDGFRAKITFGFR1FGFR2
SCHEMBL2922350 0.92 PDGFRB (1.00) PDGFRBPDGFRAKITFGFR1FGFR2
SCHEMBL13330494 0.92 PDGFRB (1.00) PDGFRBPDGFRAKITFGFR1FGFR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170172989-A1 TREATMENT OF CANCERS HAVING RESISTANCE TO CHEMOTHERAPEUTIC AGENTS BAYER HEALTHCARE LLC (US) 2017-06-22 US claimed
US-20100173954-A1 TREATMENT OF CANCERS HAVING RESISTANCE TO CHEMOTHERAPEUTIC AGENTS BAYER HEALTHCARE LLC (US) 2010-07-08 US claimed
EP-2114403-A2 TREATMENT OF CANCERS HAVING RESISTANCE TO CHEMOTHERAPEUTIC AGENTS Bayer Healthcare, LLC (US) 2009-11-11 EP claimed
WO-2008089388-A2 TREATMENT OF CANCERS HAVING RESISTANCE TO CHEMOTHERAPEUTIC AGENTS BAYER HEALTHCARE LLC (US) 2008-07-24 WO claimed
US-10308943-B2 Compositions with improved intravitreal half-life and uses thereof VITRISA THERAPEUTICS, INC. (US) 2019-06-04 US disclosed
EP-3414330-A1 COMPOSITIONS WITH IMPROVED INTRAVITREAL HALF-LIFE AND USES THEREOF Vitrisa Therapeutics, Inc. (US) 2018-12-19 EP disclosed
US-20180340179-A1 COMPOSITIONS WITH IMPROVED INTRAVITREAL HALF-LIFE AND USES THEREOF SILICON VALLEY BANK 2018-11-29 US disclosed
WO-2018148333-A1 COMPOSITIONS WITH IMPROVED INTRAVITREAL HALF-LIFE AND USES THEREOF VITRISA THERAPEUTICS, INC. (US) 2018-08-16 WO disclosed
US-20180000771-A1 AGENT FOR PREVENTING AND/OR TREATING AMYOTROPHIC LATERAL SCLEROSIS KYOTO UNIVERSITY (JP) 2018-01-04 US disclosed
WO-2017139417-A1 COMPOSITIONS WITH IMPROVED INTRAVITREAL HALF-LIFE AND USES THEREOF VITRISA THERAPEUTICS, INC. (US) 2017-08-17 WO disclosed
US-20170172989-A1 TREATMENT OF CANCERS HAVING RESISTANCE TO CHEMOTHERAPEUTIC AGENTS BAYER HEALTHCARE LLC (US) 2017-06-22 US disclosed
US-20130079246-A1 Methods and Tools for Screening Agents Exhibiting an Activity on Receptors of the Tumor Necrosis Factor Receptor Superfamily ADDEX PHARMA SA (CH) 2013-03-28 US disclosed
WO-2007059155-A1 TREATMENT OF CANCERS HAVING RESISTANCE TO CHEMOTHERAPEUTIC AGENTS BAYER PHARMACEUTICALS CORPORATION (US) 2007-05-24 WO disclosed
US-6750218-B2 INHIBITORY ACTIVITY ON PHOSPHORYLATION OF PLATELET-DERIVED GROWTH FACTOR (PDGF) RECEPTOR USEFUL FOR THE TREATMENT OF CELL-PROLIFERATIVE DISEASES SUCH AS ARTERIOSCLEROSIS, VASCULAR REOBSTRUCTION, CANCER AND GLOMERULOSCLEROSIS MILLENNIUMIUM PHARMACEUTICALS, INC. 2004-06-15 US disclosed
US-20030229077-A1 Nitrogen-containing heterocyclic compounds MATSUNO KENJI (JP) 2003-12-11 US disclosed
US-6472391-B2 INHIBIT PHOSPHORYLATION OF PDGF RECEPTOR TO HINDER ABNORMAL CELL GROWTH AND CELL WANDERING; TREATMENT OF CELL-PROLIFERATIVE DISEASES SUCH AS ARTERIOSCLEROSIS, VASCULAR REOBSTRUCTION, CANCER AND GLOMERULOSCLEROSIS. MILLENNIUM PHARMACEUTICALS, INC. 2002-10-29 US disclosed
US-20020068734-A1 Nitrogen-containing heterocyclic compounds MILLENNIUM PHARMACEUTICALS, INC. 2002-06-06 US disclosed
US-6207667-B1 USEFUL FOR THE TREATMENT OF CELL-PROLIFERATIVE DISEASES SUCH AS ARTERIOSCLEROSIS, VASCULAR REOBSTRUCTION, CANCER AND GLOMERULOSCLEROSIS KYOWA HAKKO KOGYO CO., LTD. (JP) 2001-03-27 US disclosed
US-6169088-B1 FOR THE PREVENTION OR TREATMENT OF CELL-PROLIFERATIVE DISEASES SUCH AS ARTERIOSCLEROSIS, VASCULAR REOBSTRUCTION, CANCER AND GLOMERULOSCLEROSIS KYOWA HAKKO KOGYO CO., LTD. (JP) 2001-01-02 US disclosed
EP-0882717-A1 NITROGENOUS HETEROCYCLIC COMPOUNDS KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) 1998-12-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180340179-A1 COMPOSITIONS WITH IMPROVED INTRAVITREAL HALF-LIFE AND USES THEREOF UACA, CRYAA, CRYAB PDGFRB 1282/4885PDGFRA 1584/4885KIT 4338/4885
US-20030229077-A1 Nitrogen-containing heterocyclic compounds ERBB4, NPR1, PDGFRB PDGFRB 3/4885PDGFRA 5/4885KIT 2045/4885
US-20020068734-A1 Nitrogen-containing heterocyclic compounds PDGFRB, MKI67, PDGFRA PDGFRB 1/4885PDGFRA 3/4885KIT 1535/4885
US-20180000771-A1 AGENT FOR PREVENTING AND/OR TREATING AMYOTROPHIC LATERAL SCLEROSIS WEE2, WEE1, ERBB2 PDGFRB 40/4885PDGFRA 293/4885KIT 407/4885
US-20170172989-A1 TREATMENT OF CANCERS HAVING RESISTANCE TO CHEMOTHERAPEUTIC AGENTS CDK4, TP53, ABCC1 PDGFRB 2508/4885PDGFRA 2125/4885KIT 1281/4885
US-10308943-B2 Compositions with improved intravitreal half-life and uses thereof UACA, CRYAA, CRYAB PDGFRB 1282/4885PDGFRA 1584/4885KIT 4338/4885
US-20100173954-A1 TREATMENT OF CANCERS HAVING RESISTANCE TO CHEMOTHERAPEUTIC AGENTS CDK4, TP53, ABCC1 PDGFRB 2508/4885PDGFRA 2125/4885KIT 1281/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.