Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RHOA | P61586 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18774005 | 0.89 | SMN1; SMN2 (0.89) | SMN1; SMN2MAPTMEN1KMT2ATP53 | |
| SCHEMBL12172899 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTMEN1KMT2ATP53 | |
| SCHEMBL21240932 | 0.83 | SMN1; SMN2 (0.94) | SMN1; SMN2MAPTMEN1KMT2ATP53 | |
| SCHEMBL8298268 | 0.82 | SMN1; SMN2 (0.97) | SMN1; SMN2MAPTMEN1KMT2ATDP1 | |
| SCHEMBL21923174 | 0.80 | SMN1; SMN2 (0.78) | SMN1; SMN2MAPTMEN1KMT2ATP53 | |
| SCHEMBL13841250 | 0.80 | MAPT (0.63) | SMN1; SMN2MAPTMEN1KMT2AHPGD | |
| SCHEMBL15335818 | 0.80 | MAPT (0.63) | SMN1; SMN2MAPTMEN1KMT2AHPGD | |
| SCHEMBL18265952 | 0.80 | MAPT (0.63) | SMN1; SMN2MAPTMEN1KMT2AHPGD | |
| SCHEMBL21231330 | 0.80 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTMEN1KMT2ATP53 | |
| SCHEMBL18658114 | 0.77 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557110-B2 | MAPKAP-K2; inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth; 5-[(trans-4-aminocyclohexyl)amino]-3-fluoro-6-methyl(pyrazolo[1,5-a]pyri- midin-7-yl)}(4-iodophenyl)amine | TEIJIN PHARMA LIMITED (JP) | 2009-07-07 | — | — | US | disclosed |