Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.94 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | RHOA | P61586 | 1/20 | 0.57 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8298268 | 0.96 | SMN1; SMN2 (0.97) | SMN1; SMN2NPSR1ALDH1A1MAPTMEN1 | |
| SCHEMBL18774005 | 0.94 | SMN1; SMN2 (0.89) | SMN1; SMN2NPSR1ALDH1A1MAPTMEN1 | |
| SCHEMBL21923174 | 0.87 | SMN1; SMN2 (0.78) | SMN1; SMN2NPSR1ALDH1A1MAPTMEN1 | |
| SCHEMBL10076207 | 0.86 | SMN1; SMN2 (0.74) | SMN1; SMN2NPSR1ALDH1A1MAPTMEN1 | |
| SCHEMBL21231330 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18658114 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTMEN1KMT2ATDP1 | |
| SCHEMBL13766293 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2NPSR1MAPTMEN1KMT2A | |
| SCHEMBL23713332 | 0.83 | SMN1; SMN2 (0.65) | SMN1; SMN2NPSR1MAPTMEN1KMT2A | |
| SCHEMBL15576241 | 0.82 | SMN1; SMN2 (0.74) | SMN1; SMN2NPSR1ALDH1A1ACKR3LMNA | |
| SCHEMBL18640454 | 0.82 | SMN1; SMN2 (0.74) | SMN1; SMN2NPSR1ALDH1A1ACKR3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |
| EP-2968316-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2019-08-07 | — | — | EP | disclosed |