Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 6/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264201 | 1.00 | AR (0.55) | ARKCNH2LMNAHTTTDP1 | |
| SCHEMBL12368428 | 0.89 | MAPT (0.57) | ARKCNH2LMNAHTTTDP1 | |
| SCHEMBL2267616 | 0.86 | LMNA (0.54) | ARKCNH2LMNAHTTTDP1 | |
| SCHEMBL2265188 | 0.82 | AR (0.70) | ARKCNH2LMNAHTTTDP1 | |
| SCHEMBL2264854 | 0.80 | AR (0.52) | ARKCNH2LMNAHTTTDP1 | |
| SCHEMBL2266631 | 0.80 | AR (0.52) | ARKCNH2LMNAHTTTDP1 | |
| SCHEMBL2264977 | 0.77 | AR (0.55) | ARKCNH2LMNAHTTTDP1 | |
| SCHEMBL2268411 | 0.77 | LMNA (0.51) | ARKCNH2LMNAHTTTDP1 | |
| SCHEMBL2263780 | 0.77 | LMNA (0.51) | ARKCNH2LMNAHTTTDP1 | |
| SCHEMBL2264615 | 0.76 | LMNA (0.50) | ARKCNH2LMNAHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081197-A1 | BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |