Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 17/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 13/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016889 | 0.87 | EPHX2 (0.74) | EPHX2EPHX1USP2LMNA | |
| SCHEMBL13768759 | 0.82 | EPHX2 (0.57) | EPHX2EPHX1 | |
| SCHEMBL13768417 | 0.81 | EPHX2 (0.53) | EPHX2EPHX1USP2LMNA | |
| SCHEMBL13768770 | 0.81 | EPHX2 (0.57) | EPHX2EPHX1 | |
| SCHEMBL13768777 | 0.81 | EPHX2 (0.56) | EPHX2EPHX1 | |
| SCHEMBL13768400 | 0.80 | EPHX2 (0.52) | EPHX2EPHX1USP2LMNA | |
| SCHEMBL13768764 | 0.80 | EPHX1 (0.52) | EPHX2EPHX1USP2LMNA | |
| SCHEMBL13768396 | 0.79 | EPHX2 (0.74) | EPHX2EPHX1 | |
| SCHEMBL13768780 | 0.78 | EPHX2 (0.67) | EPHX2EPHX1 | |
| SCHEMBL14071386 | 0.78 | HSD11B1 (0.51) | EPHX2EPHX1USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009086426-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION | ARETE THERAPEUTICS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2008112022-A1 | 4 -PI PERIDINYLUREA COMPOUNDS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |