Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.39 |
| ▸ | MTOR | P42345 | 8/20 | 0.39 |
| ▸ | CHIT1 | Q13231 | 2/20 | 0.38 |
| ▸ | CHIA | Q9BZP6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25949319 | 0.89 | DRD3 (0.43) | — | |
| SCHEMBL1992323 | 0.84 | CDK2 (0.43) | CDK4CDK6CCND1CDK2 | |
| SCHEMBL12558178 | 0.83 | CHRNB2 (0.49) | CDK4CDK6CCND1CDK2 | |
| SCHEMBL18081394 | 0.81 | KDM4E (0.41) | CDK4CCND1CDK2CHIT1CHIA | |
| SCHEMBL520505 | 0.80 | MAPT (0.53) | CDK4CDK6CHIT1CHIA | |
| SCHEMBL22650562 | 0.80 | PIK3CA (0.35) | CDK4CCND1CDK2PIK3CAMTOR | |
| SCHEMBL22164879 | 0.79 | MAP4K4 (0.48) | CDK4CDK6 | |
| SCHEMBL30926571 | 0.79 | MAP4K4 (0.48) | CDK4CDK6 | |
| SCHEMBL17477151 | 0.79 | MAP4K4 (0.48) | CDK4CDK6 | |
| SCHEMBL1750401 | 0.79 | MAP4K4 (0.48) | CDK4CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085185-A1 | FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS | AMGEN INC. (US) | 2009-07-09 | — | — | WO | disclosed |