SCHEMBL13769062

SCHEMBL13769062

O=C(C1CC=CO1)N1CCN(CC[C@@H]2CSC(c3cc4cc(Cl)cc(NC5CCOCC5)c4[nH]3)=N2)CC1

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SELP P16109 1/20 0.32
TYRO3 Q06418 1/20 0.32
FGFR1 P11362 1/20 0.30
FGFR2 P21802 1/20 0.30
RORC P51449 1/20 0.30
DHODH Q02127 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1277615 0.86 SELP (0.31) SELPTYRO3FGFR1FGFR2
SCHEMBL1277617 0.86 SELP (0.31) SELPTYRO3FGFR1FGFR2
SCHEMBL3030916 0.85 TYRO3 (0.36) SELPTYRO3FGFR1FGFR2
SCHEMBL1277827 0.84 CNR1 (0.36)
SCHEMBL1277829 0.84 CNR1 (0.36)
SCHEMBL3421899 0.83 VCP (0.36)
SCHEMBL3421896 0.83 VCP (0.36)
SCHEMBL1277434 0.83 CSF1R (0.31)
SCHEMBL1277437 0.83 CSF1R (0.31)
SCHEMBL1277767 0.82 KMT2A (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009082152-A2 GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT LG LIFE SCIENCES LTD. (KR) 2009-07-02 WO disclosed