Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMAD3 | P84022 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | ACP1 | P24666 | 2/20 | 0.49 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2734047 | 0.99 | SMAD3 (0.73) | SMAD3KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL1084601 | 0.91 | SMAD3 (0.71) | SMAD3KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL1084032 | 0.90 | MEN1 (0.70) | SMAD3KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL1084599 | 0.90 | SMAD3 (0.57) | SMAD3KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL13769477 | 0.89 | MEN1 (0.76) | SMAD3KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL5506324 | 0.89 | SMAD3 (0.62) | SMAD3KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL1084790 | 0.88 | SMAD3 (0.58) | SMAD3KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL295770 | 0.88 | CYP1A2 (0.61) | SMAD3KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL1084946 | 0.88 | CYP1A2 (0.61) | SMAD3KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL1084859 | 0.88 | SMAD3 (0.58) | SMAD3KMT2AMEN1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784393-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-07-01 | — | — | EP | disclosed |