Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.59 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084032 | 0.96 | MEN1 (0.70) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1084829 | 0.91 | MEN1 (0.76) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2734047 | 0.91 | SMAD3 (0.73) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13769142 | 0.89 | SMAD3 (0.71) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5506324 | 0.88 | SMAD3 (0.62) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1084705 | 0.88 | KMT2A (0.59) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14406452 | 0.88 | MEN1 (0.58) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1084519 | 0.88 | KMT2A (0.58) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1084946 | 0.87 | CYP1A2 (0.61) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1084790 | 0.87 | SMAD3 (0.58) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784393-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-07-01 | — | — | EP | disclosed |