Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.54 |
| ▸ | CCND1 | P24385 | 4/20 | 0.54 |
| ▸ | CCND2 | P30279 | 4/20 | 0.54 |
| ▸ | CCND3 | P30281 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324866 | 0.80 | RXFP1 (0.49) | ALDH1A1RXFP1MAPTTP53THRB | |
| SCHEMBL11562270 | 0.79 | KDM4E (0.49) | CDK4CCND1CCND2CCND3ALDH1A1 | |
| SCHEMBL1378586 | 0.78 | RXFP1 (0.46) | ALDH1A1RXFP1MAPTTP53THRB | |
| SCHEMBL29941396 | 0.75 | CA12 (0.53) | CDK4CCND1CCND2CCND3ALDH1A1 | |
| SCHEMBL7128827 | 0.75 | CA12 (0.53) | CDK4CCND1CCND2CCND3ALDH1A1 | |
| SCHEMBL1523271 | 0.75 | RXFP1 (0.51) | CDK4CCND1CCND2CCND3ALDH1A1 | |
| SCHEMBL9850735 | 0.74 | CNR2 (0.50) | CDK4CCND1CCND2CCND3MAPK1 | |
| SCHEMBL29712289 | 0.74 | BRD4 (0.50) | CDK4CCND1CCND2CCND3MAPT | |
| SCHEMBL2614748 | 0.74 | BRD4 (0.50) | CDK4CCND1CCND2CCND3MAPT | |
| SCHEMBL4142227 | 0.74 | PARP1 (0.37) | CDK4CCND1CCND2CCND3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4738172-B2 | — | — | 2011-08-03 | — | — | JP | claimed |
| EP-1560827-A1 | ANTI-INFECTIVE AGENTS | Abbott Laboratories (US) | 2005-08-10 | — | — | EP | claimed |
| WO-2004041818-A1 | ANTI-INFECTIVE AGENTS | ABBOTT LABORATORIES (US) | 2004-05-21 | — | — | WO | claimed |
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |