Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 5/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378586 | 0.86 | RXFP1 (0.46) | RXFP1TP53ALDH1A1MAPTCNR2 | |
| SCHEMBL1376936 | 0.80 | CDK4 (0.54) | RXFP1TP53ALDH1A1MAPTTHRB | |
| SCHEMBL1523271 | 0.70 | RXFP1 (0.51) | RXFP1TP53ALDH1A1MAPTTHRB | |
| SCHEMBL10376850 | 0.70 | ALDH1A1 (0.49) | ALDH1A1BRD4 | |
| SCHEMBL18053773 | 0.69 | OPRL1 (0.45) | — | |
| SCHEMBL10834756 | 0.69 | ALDH1A1 (0.47) | TP53ALDH1A1MAPT | |
| SCHEMBL11603962 | 0.69 | ALDH1A1 (0.50) | RXFP1TP53ALDH1A1MAPTTHRB | |
| SCHEMBL1522298 | 0.69 | ALDH1A1 (0.50) | RXFP1TP53ALDH1A1MAPTTHRB | |
| SCHEMBL15552770 | 0.68 | ATM (0.40) | TP53ALDH1A1CNR2 | |
| SCHEMBL16767854 | 0.67 | DAO (0.56) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |