Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | ARG1 | P05089 | 1/20 | 0.41 |
| ▸ | ARG2 | P78540 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12167434 | 0.86 | GAA (0.49) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL27546199 | 0.84 | GAA (0.47) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL12167484 | 0.84 | GAA (0.44) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL7508610 | 0.82 | ARG1 (0.45) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL4186191 | 0.81 | ARG1 (0.48) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL4186190 | 0.81 | ARG1 (0.48) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL24773136 | 0.80 | GAA (0.43) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL9939340 | 0.79 | GAA (0.51) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL10306175 | 0.79 | GAA (0.51) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL6197152 | 0.78 | FUCA1 (0.53) | GAAMEN1KMT2ATSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7563805-B2 | 7-[3-Amino-3,4-dimethylpyrrolidine-1-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid: quinoline bactericide; broad spectrum, strong antibacterial activity for Grampositive/-negative including multiple resistant cocci; side effect reductcion; drug design | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-07-21 | — | — | US | disclosed |