Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13769532 | 0.87 | PDE4B (0.41) | MAPTALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL13769525 | 0.85 | MAPT (0.40) | MAPTALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL13769936 | 0.84 | PDE4B (0.42) | MAPTALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL13769676 | 0.84 | MAPT (0.39) | MAPTALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL13769671 | 0.83 | SRC (0.45) | MAPTALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL13769926 | 0.83 | XDH (0.45) | MAPTALDH1A1KDM4EP2RX7PDE4B | |
| SCHEMBL13769538 | 0.82 | MAPT (0.38) | MAPTALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL13769386 | 0.82 | MAPT (0.39) | MAPTALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL13770135 | 0.81 | MAPT (0.47) | MAPTALDH1A1KDM4ETP53LMNA | |
| SCHEMBL13769533 | 0.79 | MAPT (0.44) | MAPTALDH1A1KDM4EHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |