Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.34 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.34 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.34 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13769995 | 0.94 | CHEK1 (0.46) | CHEK1GSK3BDYRK1A | |
| SCHEMBL13770146 | 0.92 | CHEK1 (0.47) | CHEK1GSK3BDYRK1A | |
| SCHEMBL13770126 | 0.91 | CHEK1 (0.42) | CHEK1 | |
| SCHEMBL13769780 | 0.88 | CHEK1 (0.35) | CHEK1RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL13770383 | 0.87 | RPS6KA2 (0.38) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL13770032 | 0.87 | CHEK1 (0.41) | CHEK1 | |
| SCHEMBL948898 | 0.87 | CHEK1 (0.42) | CHEK1RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL13770067 | 0.85 | CHEK1 (0.46) | CHEK1GSK3BDYRK1A | |
| SCHEMBL13770545 | 0.85 | KDR (0.36) | CHEK1GSK3BDYRK1ARPS6KA3RPS6KA2 | |
| SCHEMBL13769998 | 0.84 | CHEK1 (0.47) | CHEK1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093012-A1 | INDOLYL- PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY | VERNALIS (R & D) LTD (GB) | 2009-07-30 | — | — | WO | disclosed |