Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.33 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.33 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BUB1 | O43683 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL948720 | 0.84 | ALDH1A1 (0.42) | KMT2ARPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL951067 | 0.84 | KLKB1 (0.43) | KDRCHEK1KMT2ARPS6KA3RPS6KA2 | |
| SCHEMBL948277 | 0.83 | KLKB1 (0.46) | KDRCHEK1KMT2AALDH1A1POLB | |
| SCHEMBL949052 | 0.83 | KLKB1 (0.47) | KDRCHEK1RPS6KA3 | |
| SCHEMBL13770383 | 0.71 | RPS6KA2 (0.38) | KDRMEN1KMT2ARPS6KA3RPS6KA2 | |
| SCHEMBL948091 | 0.69 | ALDH1A1 (0.41) | MEN1KMT2ARPS6KA3RPS6KA2RPS6KA1 | |
| SCHEMBL950898 | 0.69 | KLKB1 (0.45) | MEN1KMT2ARPS6KA3RPS6KA2RPS6KA1 | |
| SCHEMBL947957 | 0.69 | RPS6KA2 (0.46) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6ALDH1A1 | |
| SCHEMBL951655 | 0.68 | KLKB1 (0.43) | MEN1KMT2ARPS6KA3RPS6KA2RPS6KA1 | |
| SCHEMBL949207 | 0.68 | SCD (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093012-A1 | INDOLYL- PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY | VERNALIS (R & D) LTD (GB) | 2009-07-30 | — | — | WO | disclosed |