Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | KCNA5 | P22460 | 9/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188862 | 0.82 | CYP3A4 (0.50) | KDM4EKCNA5KCNH2CHRM2CHRM1 | |
| SCHEMBL8570755 | 0.79 | CHRM2 (0.66) | KDM4EKCNH2CHRM2CHRM1HTR1A | |
| SCHEMBL1377464 | 0.77 | KCNA5 (0.54) | KDM4EKCNA5KCNH2LMNACYP1A2 | |
| SCHEMBL4556571 | 0.77 | KDM4E (0.46) | KDM4EKCNA5KCNH2CHRNB2CHRNA4 | |
| SCHEMBL1375994 | 0.75 | KCNA5 (0.43) | KDM4EKCNA5KCNH2CHRNB2CHRNA4 | |
| SCHEMBL4351220 | 0.73 | KCNA5 (0.50) | KDM4EKCNA5KCNH2CYP1A2CYP3A4 | |
| SCHEMBL4190585 | 0.71 | KCNA5 (0.47) | KDM4EKCNA5KCNH2CHRNB2CHRNA4 | |
| SCHEMBL11019493 | 0.70 | CYP11B1 (0.63) | KCNA5KCNH2CYP2D6LMNACYP1A2 | |
| SCHEMBL1380025 | 0.69 | KCNA5 (0.57) | KDM4EKCNA5KCNH2LMNACYP1A2 | |
| SCHEMBL19627972 | 0.68 | CYP19A1 (0.57) | KCNA5LMNACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4719745-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | claimed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |