Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 8/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4351220 | 0.82 | KCNA5 (0.50) | KCNA5CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11019493 | 0.82 | CYP11B1 (0.63) | KCNA5CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11019246 | 0.77 | CYP11B1 (0.50) | KCNA5CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11020545 | 0.77 | CYP19A1 (0.55) | KCNA5CYP3A4CYP19A1CYP3A5CYP11B1 | |
| SCHEMBL1377092 | 0.77 | KDM4E (0.56) | KCNA5CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11023951 | 0.72 | CYP11B1 (0.45) | KCNA5CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1380025 | 0.71 | KCNA5 (0.57) | KCNA5CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19627972 | 0.71 | CYP19A1 (0.57) | KCNA5CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11631869 | 0.70 | KCNA5 (0.65) | KCNA5CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4336663 | 0.70 | KCNA5 (1.00) | KCNA5CYP3A4CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4719745-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | claimed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |