SCHEMBL1377299

SCHEMBL1377299

Nc1ccc(C(=O)c2ccc(N)c(S(=O)(=O)O)c2)cc1S(=O)(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 1/20 0.56
ALDH1A1 P00352 4/20 0.43
GAA P10253 2/20 0.43
MAPT P10636 2/20 0.43
MAPK1 P28482 1/20 0.43
LMNA P02545 1/20 0.43
HTT P42858 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CTDSP1 Q9GZU7 1/20 0.41
TTR P02766 1/20 0.40
HSD17B10 Q99714 4/20 0.40
RAB9A P51151 2/20 0.40
NPC1 O15118 1/20 0.40
USP2 O75604 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
NQO1 P15559 1/20 0.39
AURKA O14965 1/20 0.39
AURKB Q96GD4 1/20 0.39
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10259579 0.93 CDC25B (0.50) CDC25BALDH1A1GAAMAPTMAPK1
SCHEMBL8958603 0.90 ALDH1A1 (0.52) CDC25BALDH1A1GAAMAPTMAPK1
SCHEMBL11489553 0.88 PBRM1 (0.57) CDC25BALDH1A1LMNAL3MBTL1TTR
SCHEMBL1755175 0.86 CDC25B (0.55) CDC25BALDH1A1MAPK1CTDSP1TTR
SCHEMBL1363387 0.86 CDC25B (0.76) CDC25BALDH1A1GAAMAPTLMNA
SCHEMBL9363675 0.86 CDC25B (0.44) CDC25BALDH1A1GAAMAPTMAPK1
SCHEMBL11860250 0.85 CDC25B (0.73) CDC25BALDH1A1GAAMAPTLMNA
SCHEMBL8958784 0.81 MAPT (0.48) CDC25BALDH1A1GAAMAPTMAPK1
SCHEMBL1755052 0.80 KDM4E (0.56) CDC25BALDH1A1GAAMAPTMAPK1
SCHEMBL13901547 0.80 CDC25B (0.49) CDC25BALDH1A1GAAMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1023168-B1 FIBER-REINFORCED PHTHALONITRILE COMPOSITE CURED WITH LOW-REACTIVITY AROMATIC AMINE CURING AGENT US GOV SEC NAVY (US) 2004-11-24 EP claimed
EP-1023168-A4 FIBER-REINFORCED PHTHALONITRILE COMPOSITE CURED WITH LOW-REACTIVITY AROMATIC AMINE CURING AGENT US NAVY (US) 2000-12-20 EP claimed
EP-1023168-A1 FIBER-REINFORCED PHTHALONITRILE COMPOSITE CURED WITH LOW-REACTIVITY AROMATIC AMINE CURING AGENT THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE NAVY (US) 2000-08-02 EP claimed
US-6001926-A Fiber-reinforced phthalonitrile composite cured with low-reactivity aromatic amine curing agent THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1999-12-14 US claimed
WO-1999017928-A1 FIBER-REINFORCED PHTHALONITRILE COMPOSITE CURED WITH LOW-REACTIVITY AROMATIC AMINE CURING AGENT THE GOVERNMENT OF THE UNITED STATES, REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1999-04-15 WO claimed
US-12365763-B2 Phthalonitrile resins, methods of making same and compositions thereof HUNTSMAN ADVANCED MATERIALS AMERICAS LLC 2025-07-22 US disclosed
US-20230023657-A1 Phthalonitrile Resins, Methods Of Making Same And Compositions Thereof HUNTSMAN ADVANCED MATERIALS AMERICAS LLC 2023-01-26 US disclosed
US-20220403108-A1 Curable Compositions Of Benzoxazine And Phthalonitrile Resins HUNTSMAN ADVANCED MATERIALS AMERICAS LLC 2022-12-22 US disclosed
EP-4051727-A1 PHTHALONITRILE RESINS, METHODS OF MAKING SAME AND COMPOSITIONS THEREOF Huntsman Advanced Materials Americas LLC (US) 2022-09-07 EP disclosed
EP-4051726-A1 CURABLE COMPOSITIONS OF BENZOXAZINE AND PHTHALONITRILE RESINS Huntsman Advanced Materials Americas LLC (US) 2022-09-07 EP disclosed
WO-2021087193-A1 PHTHALONITRILE RESINS, METHODS OF MAKING SAME AND COMPOSITIONS THEREOF HUNTSMAN ADVANCED MATERIALS AMERICAS LLC (US) 2021-05-06 WO disclosed
WO-2021087197-A1 CURABLE COMPOSITIONS OF BENZOXAZINE AND PHTHALONITRILE RESINS HUNTSMAN ADVANCED MATERIALS AMERICAS LLC (US) 2021-05-06 WO disclosed
EP-1507816-A1 OLIGOMERIC HYDROXY ARYLETHER PHTHALONITILES AND SYNTHESIS THEREOF THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE NAVY (US) 2005-02-23 EP disclosed
EP-1023168-B1 FIBER-REINFORCED PHTHALONITRILE COMPOSITE CURED WITH LOW-REACTIVITY AROMATIC AMINE CURING AGENT US GOV SEC NAVY (US) 2004-11-24 EP disclosed
US-20040181029-A1 Oligomeric hydroxy arylether phthalonitiles and synthesis thereof UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY, THE 2004-09-16 US disclosed
US-20040181027-A1 Oligomeric hydroxy arylether phthalonitiles and synthesis thereof NAVY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE 2004-09-16 US disclosed
US-6756470-B2 Oligomeric hydroxy arylether phthalonitiles and synthesis thereof THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY 2004-06-29 US disclosed
US-20030229198-A1 Oligomeric hydroxy arylether phthalonitiles and synthesis thereof NAVY, UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF, THE 2003-12-11 US disclosed
WO-2003091312-A1 OLIGOMERIC HYDROXY ARYLETHER PHTHALONITILES AND SYNTHESIS THEREOF THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRSENTED BY THE SECRETARY OF THE NAVY (US) 2003-11-06 WO disclosed
US-6001926-A Fiber-reinforced phthalonitrile composite cured with low-reactivity aromatic amine curing agent THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1999-12-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12365763-B2 Phthalonitrile resins, methods of making same and compositions thereof PNN, PAH, CUL4B CDC25B 3219/4885ALDH1A1 2253/4885GAA 3210/4885
US-20230023657-A1 Phthalonitrile Resins, Methods Of Making Same And Compositions Thereof PNN, PAH, CUL4B CDC25B 3219/4885ALDH1A1 2253/4885GAA 3210/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.