Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | TNF | P01375 | 3/20 | 0.53 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1374582 | 0.91 | HDAC3 (0.63) | MAPTALDH1A1TSHRHDAC3HDAC4 | |
| SCHEMBL1373966 | 0.89 | HDAC3 (0.65) | MAPTALDH1A1TSHRHDAC3HDAC4 | |
| SCHEMBL1376645 | 0.86 | HDAC3 (0.55) | MAPTALDH1A1TSHRHDAC3HDAC4 | |
| SCHEMBL1374151 | 0.85 | HDAC3 (0.67) | MAPTALDH1A1TSHRHDAC3HDAC4 | |
| SCHEMBL1374147 | 0.85 | HDAC3 (0.67) | MAPTALDH1A1TSHRHDAC3HDAC4 | |
| SCHEMBL1374554 | 0.85 | HDAC3 (0.64) | MAPTALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL1375115 | 0.82 | HDAC3 (0.63) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| SCHEMBL12088964 | 0.81 | ALDH1A1 (0.73) | MAPTALDH1A1TSHRGAATNF | |
| SCHEMBL1377318 | 0.81 | HDAC3 (0.67) | MAPTALDH1A1TSHRHDAC3HDAC4 | |
| SCHEMBL1377315 | 0.81 | HDAC3 (0.67) | MAPTALDH1A1TSHRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275810-A1 | CARBAMIC ACID COMPOUNDS COMPRISING A PIPERAZINE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LIMITED (GB) | 2011-11-10 | — | — | US | disclosed |
| US-7981895-B2 | Histone deacetylase inhibitor; anticancer agents; antiproliferative agents; antitumor agents; psoriasis; piperazine compound containing a carbamic acid group | TOPOTARGET UK LIMITED (GB) | 2011-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275810-A1 | CARBAMIC ACID COMPOUNDS COMPRISING A PIPERAZINE LINKAGE AS HDAC INHIBITORS | HDAC5, HDAC1, HDAC7 | MAPT 1214/4885ALDH1A1 1221/4885TSHR 3923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.