Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 11/20 | 0.67 |
| ▸ | HTR1B | P28222 | 8/20 | 0.67 |
| ▸ | HTR1A | P08908 | 5/20 | 0.67 |
| ▸ | HTR2A | P28223 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | HTR1F | P30939 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13773322 | 0.87 | HTR1D (0.53) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL4087151 | 0.86 | HTR1D (0.62) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL4087159 | 0.86 | HTR1D (0.62) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL4077874 | 0.84 | HTR1D (0.60) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL4077871 | 0.84 | HTR1D (0.60) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Hydrochloric Acid SCHEMBL6478835 | 0.83 | HTR1D (0.59) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL4427888 | 0.80 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL33336 | 0.80 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL14861150 | 0.80 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL40595 | 0.80 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7563904-B2 | Synthesis intermediates useful for preparing zolmitriptan | INKE, S.A. (ES) | 2009-07-21 | — | — | US | disclosed |
| US-20080306279-A1 | Synthesis Intermediates Useful For Preparing Zolmitriptan | INKE, S.A. (ES) | 2008-12-11 | — | — | US | disclosed |
| US-7342035-B2 | Reduction, acidification of aniline diazonium salt ; In situ reaction of hydrazine hydrochloride with alpha-keto-delta-valerolactone; Fischer indole synthesis of hydrazone; Transesterification of pyranoindolone; Conversion of hydroxyl group into amino; Saponification, decarboxylation of indolecarboxylate | INKE, S.A. (ES) | 2008-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306279-A1 | Synthesis Intermediates Useful For Preparing Zolmitriptan | CYP51A1, CYP4A11, TPSD1 | HTR1D 334/4885HTR1B 416/4885HTR1A 436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.