Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3957943 | 1.00 | AKR1C3 (0.41) | AKR1C3AKR1C2CCR1TRPV3STK17B | |
| SCHEMBL3954260 | 0.84 | PDE2A (0.40) | AKR1C3AKR1C2CCR1STK17BJAK2 | |
| SCHEMBL3955731 | 0.82 | PDE2A (0.48) | AKR1C3AKR1C2CCR1STK17BJAK2 | |
| SCHEMBL3102048 | 0.81 | PSEN1 (0.42) | AKR1C3AKR1C2CCR1TRPV3STK17B | |
| SCHEMBL13780404 | 0.81 | MAPT (0.45) | AKR1C3AKR1C2CCR1STK17BJAK2 | |
| SCHEMBL3953794 | 0.81 | PDE2A (0.44) | AKR1C3AKR1C2CCR1STK17BJAK2 | |
| SCHEMBL6385083 | 0.78 | CCR1 (0.39) | AKR1C3AKR1C2CCR1TRPV3STK17B | |
| SCHEMBL3954885 | 0.78 | PPARD (0.38) | CCR1TRPV3STK17BJAK2PSEN1 | |
| SCHEMBL3954123 | 0.78 | JAK2 (0.36) | AKR1C3AKR1C2CCR1STK17BJAK2 | |
| SCHEMBL2245501 | 0.77 | CCR1 (0.40) | CCR1STK17BJAK2PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176863-A1 | THIOPHENE DERIVATIVE PPAR MODULATORS | MANTLO NATHAN BRYAN | 2009-07-09 | — | — | US | disclosed |
| US-7504433-B2 | Thiophene derivative PPAR modulators | ELI LILLY AND COMPANY (US) | 2009-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176863-A1 | THIOPHENE DERIVATIVE PPAR MODULATORS | PPARA, PPARG, PPARD | AKR1C3 798/4885AKR1C2 824/4885CCR1 1210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.